Site-2 proteases (S2P) belong to the M50 family of metalloproteases, which typically perform essential roles by mediating activation of membrane-bound transcription factors through regulated intramembrane proteolysis (RIP).Protease-dependent liberation of dormant transcription factors triggers diverse cellular responses, such as sterol regulation,
BackgroundThe Hajj pilgrimage, a significant spiritual journey for Muslims, occurs annually in Mecca, Saudi Arabia, attracting millions of participants from diverse backgrounds worldwide.This surge in pilgrims poses substantial challenges for healthcare services, as many face health risks due to physical exertion, dehydration, and exposure to infec
Abstract Background Metastases are the major cause of cancer-related morbidity and mortality.By the time cancer cells detach from their primary site to eventually spread to distant sites, they need to acquire the ability to survive in non-adherent conditions and to proliferate within a new microenvironment in spite of stressing conditions that may
BackgroundIt has often been reported that young people are at high risk of mental health concerns, more so than at any other time in development over their life span.The situational factors that young people report as impacting their well-being are not addressed as often: specifically, family discord.Kids Helpline, a national service in Australia t
As of today, according to the classifications of ecosystem services, there were developed numerous methods of their assessment.At the same time, there are no studies on institutional support for ecosystems depending on their functional groups.If we want to achieve economic effects in our economic activity in the process of support and improvement o